Clinical Pathology

• Hematology
  • Simultaneous evaluation of complete blood counts (red blood cell counts, white blood cell counts, platelet counts, hemoglobin and hematocrit measurements), white blood cell differential counts and reticulocyte counts/ratios using a hematoanalyzer).
  • Microscopic measurement of reticulocytes by supravital staining and calculation of white blood cell differential (ratio) in blood smears.

• Blood coagulation/fibrinolysis
  • Measurements of prothrombin time, activated partial thromboplastin time, fibrinogen and coagulation factor activities using a coagulator.
  • D-dimer and fibrin/fibrinogen degradation product (FDP) measurements using commercial reagents.
  • Measurement of platelet aggregation ability.

• Myelograms
  Calculations of bone marrow nuclear cell counts and cell fractions (ratios) by microscopic examination of bone marrow smears taken from the femur of rats or the ribs of canines or non-human primates.

• Clinical chemistry
  Measurements of proteins, enzymes, low molecular weight nitrogenous compounds, glucose, lipids, electrolytes, pigments and novel biomarkers (GLDH).

• Analysis of protein and lipid fractions, isozymes
  Measurements of protein fractions, lipid fractions (lipoprotein, CH, TG) and isozymes (ALP, LDH, CK) by agarose gel electrophoresis.

• Toxicity biomarker analysis
  Various measurements (Troponin I, Clusterin, etc.) using commercially-available ELISA kits.

• Bone biomarker analysis
  Various measurements (OC, PYD, DPD, NTX, CTX, etc.) using commercially-available ELISA kits.

• Flow cytometric analysis of cell surface antigens
  Measurement of lymphocyte subsets (T cells (CD4 and CD8), B cells and NK cells) using a six-color flow cytometer.

• Analysis of blood gases
  Analysis of blood gases (pH, O2, CO2).

• Urinalysis
  • Analysis of parameters such as urine volume, color, specific gravity, osmotic pressure, qualitative and semiquantitation tests using reagent strips and quantitation of urinary electrolytes.
  • Determination of urinary composition including protein and NAG.

• Other
  • Immunological tests (Coombs' test, etc.), fecalysis, hemolysis tests.
  • Collection of blood and organ samples