Ina Research Inc. (INA) offers toxicity studies for pharmaceuticals, medical devices, agricultural and other chemical substances, food products and more. We also offer complete support services for a full-range of non-clinical toxicity studies for pharmaceutical development, from the screening stage to preparation for clinical trials. GLP-compliant services are conducted at our fully AAALAC International-accredited facility, and our team of experts are always available for timely communications.
General toxicity
Single, as well as short and long-term repeated-dose toxicity studies, are possible at INA. Our team of experienced researchers includes certified toxicologists, pathologists and doctorate holders, and is supported by certified laboratory animal technicians. The various tests required for entering Phase I clinical trials, including genotoxicity and safety pharmacology studies, can be completed, from initial testing to final report submission, in as little as 6 months.
Reproductive and developmental toxicity
INA possesses extensive experience and historical data for reproductive and developmental toxicity studies in all areas deemed necessary by ICH guidelines.
Genotoxicity
Our staff possess vast experience in screening, as well as the various toxicity studies necessary for New Drug Applications.
Carcinogenicity
INA's expertise lies in accurate tumor diagnosis, and we can also offer peer-reviews by leading tumor pathologists from both Japan and abroad.
Screening Toxicity
INA can propose the appropriate study design, using minimal amounts of test article to best suit your developmental needs. By periodically measuring blood drug concentration, it is also possible to check the exposure to or accumulation of a drug at each dose level. Seperate PK and TK screening studies are also available.
Biological safety tests on medical devices
INA conducts various biological safety studies on medical devices and raw materials.
- Cytotoxicity (extraction and direct contact methods)
- Sensitization
- Irritation
- Systemic toxicity
- Implantation
- Genotoxicity
- Hemocompatibility
- Effects of contact lenses on the cornea
Other
In addition to general toxicity studies, our experienced technicians also conduct other specialty toxicity studies, including functional tests, all conducted in accordance with international guidelines.
- Ocular toxicity
- Renal toxicity
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