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AAALAC International AAALAC International Ina Research Inc. is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International. AAALAC International is a private, non-profit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. More than 900 companies, universities, hospitals, government agencies and other research institutions in 39 countries around the world have earned AAALAC International accreditation. Ina Research Inc. was the first facility to be accredited in Japan, on February 22, 2005. AAALAC International Accreditation Site visit Result 1 Nov. 16-17, 2004 Fully accredited on Feb. 22, 2005 2 Nov. 12-13, 2007 Accreditation extended on Mar. 5, 2008

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Corporate Governance Mission It is our wish for the eternal peaceful coexistence of all humankind. We strive to achieve this goal through the exploration of life sciences and by contributing to the maintenance of the global environment, to make healthcare of the future a reality. To accomplish this aim, we strive to always: １．focus on society, and work on things we should do and that only we can do. ２．keep the spirit of investigation and imagination alive. ３．make the best efforts to trust others and to be trusted by them. Principles It is our wish for the eternal peaceful coexistence of all humankind. We strive to achieve this goal through the exploration of life sciences and by contributing to the maintenance of the global environment, to make healthcare of the future a reality. Vision In order to put the above principles into practice,

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Offices About Ina City About Ina City Ina Research Inc. is located in Ina City, southern Nagano Prefecture. With the Southern Alps to the east, the Central Alps to the west, and the Tenryu and Mibu Rivers flowing through its center, Ina City is surrounded by rich and abundant nature. Access to Ina-City ■Train (JR) INA-SHI Stations, JR Iida Line(From the Tokyo area about 3 hours 30 minutes,from the Nagoya area about 3 hours 30 minutes.) ■ Car Chuo Expressway INA Exit(From the Tokyo area about 3 hours,from the Nagoya area about 2 hours 30 minutes.) ■Highway Bus INA-INTER-MAE bus stop(From the Tokyo area about 3 hours 20 minutes,from the Nagoya

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Corporate History 1974 July Founding of Shinshu Non-Clinical Laboratory Center (private limited company) 1978 March Incorporated 1983 April Pharmaceutical GLP enforcement and started GLP studies 1986 August Started Agricultural Chemicals GLP study 1989 July Changed company name to Ina Research Inc. 1994 April Established a subsidiary INARP in the Philippines 2003 April Completion of Building 5 2005 February Full accreditation from AAALAC International 2005 December Completion of Building 6 2008 June Listed on the Japanese stock market (Tokyo Securities Exchange Co., Ltd.). 2008 July Completion of Building 7 2010 January Completion of Building 8 2016 December Joint research with Yuji Shiba, Shinshu University, published in Nature 2019 November Shinshu University

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Corporate Overview Company name Ina Research Inc. Founded July 13, 1974 Incorporated March 11, 1978 Paid Up Capital 99 milion yen President & CEO Terumasa Hirai Head office 2148-188 Nishiminowa, Ina-shi, Nagano-ken 399-4501 Japan Employees 200 Research Services Non-Clinical Studies Toxicology, Safety Pharmacology, Drug Dependence, Drug Efficacy Pharmaceuticals, Agricultural Chemicals, Health Food Development Services Development Consulting Sales Office TOKYO (Chuo-ku, Tokyo)

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Message Ina Research Inc. joined the SNBL (Shin Nippon Biomedical Laboratories) Group in August of 2022, a move that empowered us to offer an even wider range of technologies and services along with enhanced flexibility. With the increase in demand for the latest testing methods and analyses in pharmaceutical development, we have been actively assimilating these rapidly evolving innovative technologies to accommodate the needs of our clients. Regarding our services, we excel at safety studies for advanced technologies such as small molecules, biopharmaceuticals and gene therapies; advanced analytics such as imaging; SEND, our long-held strength; and support for regulatory submission. We conduct nonclinical studies required for the development of test

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Archives We properly maintain study-related materials (raw data and other documents, specimens, test article samples, etc.) in a dedicated, GLP-compliant storage facility located at our head office.We regularly check the condition of archived materials and treat them carefully throughout the designated contract period.

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Translation INA offers translation services for a variety of non-clinical studies from Japanese to English and vice versa, not limited to studies contracted at INA. Our high-quality translations are carried out with the support of in-house experts and external consultants, including native English-speaking scientists. Translation services Translation services ■ Non-clinical study protocols/reports for pharmaceuticals, chemical/agrichemical products and cosmetics. ■ Investigational New Drug publications, Investigator’s Brochures, references, etc. Experience ■General toxicity ■Reproductive and developmental toxicity ■Carcinogenicity ■Irritation ■Genotoxicity ■Pharmacology ■Drug dependence ■Pharmacokinetics ■Investigator’s Brochure

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Published Papers Papers which Ina Research has published are as follows: Published Papers (2015-) Year Published Paper 2019 Anzai T, Matsuyama T, Wasko M, Hatakeyama H, Horikawa S, Anzai R, Iwata H, Imai N, Mizuhashi F, Tsuboi M, Okuzono T, Takagi H, Cho H, Bryan Tan Siang Rong, Masaki F, and Nakae D. Establishment of the Global SEND Alliance (G-SEND) in Japan and efficient creation of electronic SEND datasets between CROs. J. Toxicol Pathol. Vol.32, 119–126 (2019) 2019 Yamagiwa Y, Takei Y , Koizumi H, Nemoto S, Kurata M, Satoh H. Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone. Toxicol Pathol. Vol.47, 26–34

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Quality Assurance Quality Assurance INA provides reliable data of the highest quality for all studies. Education All study personnel receive periodic education on GLP regulations and experimental techniques. Quality Control (QC) system A thorough QC checking system is in place for the entire duration of all studies (GLP and non-GLP), including protocol preparation, study procedures and report preparation. Each technician and researcher double checks their own work, which is followed by further checks from their superiors and the study director. At the final report-writing stage, consistency with the raw data is checked by both researchers and the report preparation section. Quality Assurance Unit (QAU) Our QAU audits all GLP-compliant study