{"id":3256,"date":"2019-03-22T15:13:14","date_gmt":"2019-03-22T06:13:14","guid":{"rendered":"https:\/\/www.ina-research.co.jp\/service\/agrichemicals"},"modified":"2024-03-25T09:42:36","modified_gmt":"2024-03-25T00:42:36","slug":"agrichemicals","status":"publish","type":"page","link":"https:\/\/www.ina-research.co.jp\/en\/service\/agrichemicals","title":{"rendered":"Agrichemicals"},"content":{"rendered":"\n

Safety Assessment of Agrichemicals<\/h1>\n\n\n\n
\"\"<\/figure>\n\n\n\n

SNBL INA Ltd. supports a comprehensive range of toxicity tests required in applications for registration of new agricultural chemicals, starting from the screening stage. As a GLP-compliant, AAALAC-accredited* facility, our in vivo<\/em>\/in vitro<\/em> tests also comply with OECD guidelines and country-specific regulations related to applications and safety assessments for new agricultural chemicals. Upon your request, we also offer consulting services on toxicity evaluation taking into account the regulations of each country.      \u3000\u3000\u3000<\/p>\n\n\n\n

 *Association for Assessment and Accreditation of Laboratory Animal Care International<\/sub><\/p>\n\n\n\n

<\/div>\n\n\n\n

General Toxicity Tests (compliant with OECD Test Guidelines)<\/h2>\n\n\n\n
    \n
  • OECD TG 420\u3001OECD TG 423
                              Acute Oral Toxicity<\/li>\n\n\n\n
  • OECD TG 402\u3000Acute Dermal Toxicity<\/li>\n\n\n\n
  • OECD TG 407\u3000Repeated Dose 28-Day Oral Toxicity Study in Rodents<\/li>\n\n\n\n
  • OECD TG 408\u3000Repeated Dose 90-Day Oral Toxicity Study in Rodents<\/li>\n\n\n\n
  • OECD TG 409\u3000Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents<\/li>\n\n\n\n
  • OECD TG 410\u3000Repeated Dose Dermal Toxicity: 21\/28-Day Study<\/li>\n\n\n\n
  • OECD TG 411\u3000Subchronic Dermal Toxicity: 90-Day Study <\/li>\n\n\n\n
  • OECD TG 452\u3000Chronic Toxicity Studies<\/li>\n<\/ul>\n\n\n\n

    \u3000     Observations, Examinations and Measurements: <\/strong>
              \u30fbClinical observations, body weights, food and water consumption, ophthalmology, urinalysis,
                hematology, clinical chemistry, gross pathology, organ weights and histopathology
              \u30fbOptional: auditory test, ECG, blood pressure, body temperature and thyroid-related hormones
    \u3000\u3000\u3000 (T3, T4, TSH)<\/p>\n\n\n\n

      \n
    • Analysis of dosing formulation: stability, homogeneity, verification of concentrations (solution, suspension, feed, including validation)<\/li>\n\n\n\n
    • Toxicokinetics: determination of test article and metabolite concentrations in biological samples (including validation)<\/li>\n<\/ul>\n\n\n\n
      <\/div>\n\n\n\n

      Genotoxicity Tests (compliant with OECD Test Guidelines)<\/h2>\n\n\n\n
        \n
      • OECD TG 471\u3000Bacterial Reverse Mutation Test (Ames test)<\/li>\n\n\n\n
      • OECD TG 473\u3000In Vitro<\/em> Mammalian Chromosomal Aberration Test<\/li>\n\n\n\n
      • OECD TG 474\u3000Mammalian Erythrocyte Micronucleus Test (bone marrow, peripheral blood, liver)
                                   ▶ Evidence of systemic exposure can also be provided.<\/li>\n\n\n\n
      • OECD TG 475\u3000Mammalian Bone Marrow Chromosomal Aberration Test<\/li>\n\n\n\n
      • OECD TG 487\u3000In Vitro<\/em> Mammalian Cell Micronucleus Test (TK6, CHL\/IU)
                                   ▶ Tests using Cytochalasin B also available.<\/li>\n\n\n\n
      • OECD TG 489\u3000In Vivo<\/em> Mammalian Alkaline Comet Assay (liver, stomach, bone marrow, urinary bladder)<\/li>\n\n\n\n
      • OECD TG 490\u3000In Vitro<\/em> Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene<\/li>\n<\/ul>\n\n\n\n
        <\/div>\n\n\n\n

        Reproduction and Development Toxicity Tests
        (compliant with OECD Test Guidelines)<\/h2>\n\n\n\n
          \n
        • OECD TG 414\u3000Prenatal Developmental Toxicity Study<\/li>\n\n\n\n
        • OECD TG 416\u3000Two-Generation Reproduction Toxicity<\/li>\n\n\n\n
        • OECD TG 421\u3000Reproduction\/Developmental Toxicity Screening Test<\/li>\n\n\n\n
        • OECD TG 443\u3000Extended One-Generation Reproductive Toxicity Study (Cohort 1A, 1B, 2A, 2B)<\/li>\n\n\n\n
        • OECD TG 422\u3000Combined Repeated Dose Toxicity Study with the Reproduction\/Developmental
                                    Toxicity Screening Test<\/li>\n<\/ul>\n\n\n\n
          <\/div>\n\n\n\n

          Carcinogenicity Tests (compliant with OECD Test Guidelines)<\/h2>\n\n\n\n
            \n
          • Short-term Carcinogenicity Studies<\/li>\n\n\n\n
          • OECD TG 453\u3000Combined Chronic Toxicity\/Carcinogenicity Studies<\/li>\n<\/ul>\n\n\n\n
            <\/div>\n\n\n\n

            Irritation Tests (compliant with OECD Test Guidelines)<\/h2>\n\n\n\n
              \n
            • OECD TG 404\u3000Acute Dermal Irritation\/Corrosion<\/li>\n\n\n\n
            • OECD TG 405\u3000Acute Eye Irritation\/Corrosion<\/li>\n\n\n\n
            • OECD TG 439\u3000In Vitro<\/em> Skin Irritation: Reconstructed Human Epidermis Test Methods (cultured cells)<\/li>\n\n\n\n
            • OECD TG 492\u3000Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying
                                        chemicals not requiring classification and labelling for eye irritation or serious eye
                                        damage (cultured cells)<\/li>\n<\/ul>\n\n\n\n
              <\/div>\n\n\n\n

              Sensitization Tests (compliant with OECD Test Guidelines)<\/h2>\n\n\n\n
                \n
              • OECD TG 406\u3000Skin Sensitisation Guinea Pig Maximisation Test and Buehler Test<\/li>\n\n\n\n
              • OECD TG 442B Local Lymph Node Assay: BrdU-ELISA\n
                <\/div>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

                Safety Assessment of Agrichemicals SNBL INA Ltd. supports a comprehensive range of toxicity tests required in applications for registration of new agricultural chemicals, starting from the screening stage. As a GLP-compliant, AAALAC-accredited* facility, our in vivo\/in vitro tests also comply with OECD guidelines and country-specific regulations related to applications and safety assessments for new agricultural chemicals. Upon your request, we also offer consulting services on toxicity evaluation taking into account the regulations of each country.      \u3000\u3000\u3000  *Association for Assessment and Accreditation of Laboratory Animal Care International General Toxicity Tests (compliant with OECD Test Guidelines) \u3000     Observations, Examinations and Measurements:           \u30fbClinical observations, body weights, food and water consumption, ophthalmology, urinalysis,            hematology, clinical chemistry, gross pathology,<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2830,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/www.ina-research.co.jp\/en\/wp-json\/wp\/v2\/pages\/3256"}],"collection":[{"href":"https:\/\/www.ina-research.co.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ina-research.co.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ina-research.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ina-research.co.jp\/en\/wp-json\/wp\/v2\/comments?post=3256"}],"version-history":[{"count":7,"href":"https:\/\/www.ina-research.co.jp\/en\/wp-json\/wp\/v2\/pages\/3256\/revisions"}],"predecessor-version":[{"id":9109,"href":"https:\/\/www.ina-research.co.jp\/en\/wp-json\/wp\/v2\/pages\/3256\/revisions\/9109"}],"up":[{"embeddable":true,"href":"https:\/\/www.ina-research.co.jp\/en\/wp-json\/wp\/v2\/pages\/2830"}],"wp:attachment":[{"href":"https:\/\/www.ina-research.co.jp\/en\/wp-json\/wp\/v2\/media?parent=3256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}